Oksitosin

OXT
Pengecam
Alias	OXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
Pengecam-pengecam luaran	OMIM: 167050 MGI: 97453 HomoloGene: 55494 GeneCards: OXT
Kedudukan gen (Manusia)
Kr.	Kromosom 20
Tamat	3,072,517 bp
Corak ekspresi RNA
	Top expressed in
	oocyte; ; Testis; ; Hipotalamus; ; gonad; ; right lobe of liver; ; secondary oocyte; ; Desidua; ; Pituitari anterior; ; subcutaneous adipose tissue; ; right adrenal gland;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; tibiofemoral joint; ; nucleus of stria terminalis; ; right ventricle; ; median eminence; ; gastrula; ; leher; ; lateral hypothalamus;
	More reference expression data
	tiada data
Ontologi gen
Fungsi molekul	oxytocin receptor binding; hormone activity; neurohypophyseal hormone activity; neuropeptide hormone activity;
Komponen sel	terminal bouton; extracellular region; Sitoplasma; secretory granule; Ekstrasel;
Proses biologi	response to amphetamine; regulation of digestive system process; Pancutan mani; positive regulation of hindgut contraction; kehamilan betina; positive regulation of penile erection; response to steroid hormone; Transduksi isyarat; response to activity; regulation of heart rate; response to sucrose; positive regulation of ossification; positive regulation of synapse assembly; drinking behavior; hyperosmotic salinity response; male mating behavior; positive regulation of cytosolic calcium ion concentration; response to estradiol; regulation of sensory perception of pain; response to cAMP; response to cocaine; response to progesterone; positive regulation of blood pressure; heart development; negative regulation of urine volume; response to organic cyclic compound; negative regulation of gastric acid secretion; positive regulation of prostaglandin secretion; response to peptide hormone; Maternal behavior; negative regulation of blood pressure; ingatan; positive regulation of norepinephrine secretion; tingkah laku organisma sosial; response to glucocorticoid; grooming behavior; response to prostaglandin E; eating behavior; response to ether; positive regulation of female receptivity; tidur; maternal aggressive behavior; positive regulation of synaptic transmission; response to electrical stimulus; positive regulation of uterine smooth muscle contraction; response to food; response to retinoic acid; positive regulation of renal sodium excretion; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sumber:Amigo / QuickGO
Ortolog
	5020
	18429
	ENSG00000101405
	ENSMUSG00000027301
	P01178
	P35454
	NM_000915
	NM_011025
	NP_000906
	NP_035155
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Oksitosin
Data klinikal
Sebutan	/ˌɒksɪˈtoʊsɪn/
Data fisiologi
Sumber tisu	Kelenjar pituitari
Tisu sasaran	Meluas
Reseptor	Reseptor oksitosin
Antagonis	Atosiban
Pelopor	prepropeptida oksitosin/neurofisin I
Metabolisme	Hati dan oksitosinase lain
Data farmakokinetik
Pengikatan protein	30%
Metabolisme	Hati dan oksitosinase lain
Penyingkiran separuh hayat	1–6 minit (IV); ~2 jam (intranasal)
Perkumuhan	Hempedu dan buah pinggang
Pengecam
	Nama IUPAC 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oksoetil)-10-(3-amino-3-oksopropil)-16-(4-hidroksibenzil)-13-[(1S)-1-metilpropil]-6,9,12,15,18-pentaokso-1,2-ditia-5,8,11,14,17-pentaazasikloikosan-4-il}karbonil)-L-prolil-L-leusilglsiinamida;
Nombor CAS	50-56-6 ;
PubChem CID	439302;
IUPHAR/BPS	2174;
DrugBank	DB00107 ;
ChemSpider	388434 ;
UNII	1JQS135EYN;
KEGG	D00089 ;
ChEBI	CHEBI:7872 ;
ChEMBL	ChEMBL395429 ;
CompTox Dashboard (EPA)	DTXSID8048361 ;
ECHA InfoCard	100.000.045
Data kimia dan fizikal
Formula	C43H66N12O12S2
Jisim molar	1,007.19 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O;
	InChI InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 ; Key:XNOPRXBHLZRZKH-DSZYJQQASA-N ;
	(verify)

Oksitosin [ok-si-to-sin] (oxytocin, Oxt) adalah sejenis hormon peptida dan neuropeptida yang biasa dihasilkan di hipotalamus dan dikeluarkan oleh hipofisis posterior. Ia memainkan peranan dalam menjalinkan hubungan dan pembiakan seks; malah juga semasa dan selepas melahirkan anak di mana ia mendorong pelepasan hormon ke dalam saluran darah sebagai tindak balas kepada peregangan serviks dan rahim semasa kelahiran. Ini membantu dengan kelahiran, ikatan dengan bayi serta pengeluaran susu (bersama rangsangan puting payudara dari menyusu).