Vasopresin

AVP
Pengecam
Alias	AVP, ADH, ARVP, AVP-NPII, AVRP, VP, AVP gene, AVP (gene), Prepro-AVP-NP II, arginine vasopressin gene, vasopressin gene, prepro-arginine-vasopressin-neurophysin II gene, vasopressin-neurophysin II-copeptin, vasopressin-neurophysin 2-copeptin, prepro-AVP2
Pengecam-pengecam luaran	OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Kedudukan gen (Manusia)
Kr.	Kromosom 20
Tamat	3,084,724 bp
Corak ekspresi RNA
	Top expressed in
	Hipotalamus; ; internal globus pallidus; ; gastric mucosa; ; apex of heart; ; human kidney; ; monocyte; ; left testis; ; amygdala; ; Pituitari anterior; ; right adrenal cortex;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; arcuate nucleus; ; optic nerve; ; median eminence; ; suprachiasmatic nucleus; ; nucleus of stria terminalis; ; ventromedial nucleus; ; lateral hypothalamus; ; bulu;
	More reference expression data
	Rujukan lanjutan untuk data ekspresi
Ontologi gen
Fungsi molekul	protein kinase activity; hormone activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; neurohypophyseal hormone activity; signaling receptor binding; V1A vasopressin receptor binding; V1B vasopressin receptor binding; neuropeptide hormone activity;
Komponen sel	extracellular region; cytosol; clathrin-coated vesicle membrane; Ekstrasel; secretory granule; Dendrit;
Proses biologi	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; Pencerutan pembuluh darah; negative regulation of release of cytochrome c from mitochondria; ERK1 and ERK2 cascade; water transport; cell-cell signaling; negative regulation of apoptotic process; protein kinase C signaling; generation of precursor metabolites and energy; positive regulation of peptidyl-serine phosphorylation; positive regulation of gene expression; renal water homeostasis; Transduksi isyarat; proses apoptosis; membrane organization; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; maternal aggressive behavior; positive regulation of systemic arterial blood pressure; positive regulation of cytosolic calcium ion concentration; negative regulation of female receptivity; grooming behavior; locomotory behavior; positive regulation of cell population proliferation; positive regulation of glutamate secretion; response to organic cyclic compound; positive regulation of cell growth; positive regulation of prostaglandin biosynthetic process; positive regulation of cellular pH reduction; response to testosterone; response to nicotine; tingkah laku organisma sosial; regulation of renal sodium excretion; hyperosmotic salinity response; Maternal behavior; Ereksi; response to ethanol; positive regulation of vasoconstriction; multicellular organismal water homeostasis; negative regulation of transmission of nerve impulse;
	Sumber:Amigo / QuickGO
Ortolog
	551
	11998
	ENSG00000101200
	ENSMUSG00000037727
	P01185
	P35455
	NM_000490
	NM_009732
	NP_000481
	NP_033862
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Vasopresin
Data klinikal
Sebutan	/ˌveɪzoʊˈprɛsɪn/
Nama lain	Hormon antidiuretik (ADH); vasopresin arginina (AVP); argipresin
Kod ATC	H01BA01 (WHO) ;
Data fisiologi
Sumber tisu	Nukleus supraoptik; Nukleus paraventrikular hipotalamus
Tisu sasaran	Seluruh sistem
Reseptor	V1A, V1B, V2, OXTR
Agonis	Felipresin, desmopresin
Antagonis	Diuretik
Metabolisme	Secara utamanya di hati dan ginjal
Data farmakokinetik
Pengikatan protein	1%
Metabolisme	Secara utamanya di hati dan ginjal
Penyingkiran separuh hayat	10–20 minit
Perkumuhan	Urin
Pengecam
	Nama IUPAC 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide;
Nombor CAS	11000-17-2 ;
PubChem CID	644077;
IUPHAR/BPS	2168;
DrugBank	DB00067 ;
ChemSpider	559126 ;
UNII	Y4907O6MFD;
KEGG	D00101 ;
ChEBI	CHEBI:9937 ;
ChEMBL	ChEMBL373742 ;
CompTox Dashboard (EPA)	DTXSID0048349 ;
Data kimia dan fizikal
Formula	C46H65N15O12S2
Jisim molar	1,084.24 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
Ketumpatan	1.6±0.1 g/cm3
	SMILES c1ccc(cc1)C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N;
	InChI InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1 ; Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N ;

Vasopresin manusia, juga dipanggil hormon antidiuretik (ADH), vasopresin arginina (AVP) atau argipresin, ialah hormon yang disintesis daripada gen AVP sebagai prohormon peptida dalam neuron di hipotalamus otak, dan ditukar kepada AVP. Ia kemudian bergerak ke bawah akson yang berakhir di pituitari posterior, dan dilepaskan daripada vesikel ke dalam peredaran sebagai tindak balas kepada hipertonisiti cecair luar sel (hiperosmolaliti). AVP mempunyai dua fungsi utama. Pertama, ia meningkatkan jumlah air tanpa zat terlarut yang diserap kembali ke dalam sistem peredaran daripada turasan dalam tubul ginjal di nefron. Kedua, AVP menyempitkan arteriol lalu meningkatkan rintangan vaskular periferi dan meningkatkan tekanan darah arteri.

Fungsi ketiga adalah mungkin. Sesetengah AVP mungkin dilepaskan terus ke otak dari hipotalamus, dan mungkin memainkan peranan penting dalam tingkah laku sosial, motivasi seksual dan hubungan pasangan, dan tindak balas ibu terhadap tekanan.

Vasopressin mendorong pembezaan sel asas menjadi kardiomiosit (sel otot jantung) dan menggalakkan homeostasis otot jantung.

Ia mempunyai separuh hayat yang sangat singkat, antara 16 dan 24 minit.