Subunit hemoglobin beta

HBB
Struktur sedia ada
PDB	Pencarian ortolog: PDBe RCSB
Senarai kod PDB
	6HBW, 1A00, 1A01, 1A0U, 1A0Z, 1A3N, 1A3O, 1ABW, 1ABY, 1AJ9, 1B86, 1BAB, 1BBB, 1BIJ, 1BUW, 1BZ0, 1BZ1, 1BZZ, 1C7B, 1C7C, 1C7D, 1CBL, 1CBM, 1CH4, 1CLS, 1CMY, 1COH, 1DKE, 1DXT, 1DXU, 1DXV, 1FN3, 1G9V, 1GBU, 1GBV, 1GLI, 1GZX, 1HAB, 1HAC, 1HBA, 1HBB, 1HBS, 1HCO, 1HDB, 1HGA, 1HGB, 1HGC, 1HHO, 1IRD, 1J3Y, 1J3Z, 1J40, 1J41, 1J7S, 1J7W, 1J7Y, 1JY7, 1K0Y, 1K1K, 1KD2, 1LFL, 1LFQ, 1LFT, 1LFV, 1LFY, 1LFZ, 1LJW, 1M9P, 1MKO, 1NEJ, 1NIH, 1NQP, 1O1I, 1O1J, 1O1K, 1O1L, 1O1M, 1O1N, 1O1O, 1O1P, 1QI8, 1QSH, 1QSI, 1QXD, 1QXE, 1R1X, 1R1Y, 1RPS, 1RQ3, 1RQ4, 1RQA, 1RVW, 1SDK, 1SDL, 1THB, 1UIW, 1VWT, 1XXT, 1XY0, 1XYE, 1XZ2, 1XZ4, 1XZ5, 1XZ7, 1XZU, 1XZV, 1Y09, 1Y0A, 1Y0C, 1Y0D, 1Y0T, 1Y0W, 1Y22, 1Y2Z, 1Y31, 1Y35, 1Y45, 1Y46, 1Y4B, 1Y4F, 1Y4G, 1Y4P, 1Y4Q, 1Y4R, 1Y4V, 1Y5F, 1Y5J, 1Y5K, 1Y7C, 1Y7D, 1Y7G, 1Y7Z, 1Y83, 1Y85, 1Y8W, 1YDZ, 1YE0, 1YE1, 1YE2, 1YEN, 1YEO, 1YEQ, 1YEU, 1YEV, 1YFF, 1YG5, 1YGD, 1YGF, 1YH9, 1YHE, 1YHR, 1YIE, 1YIH, 1YVQ, 1YVT, 1YZI, 2D5Z, 2D60, 2DN1, 2DN2, 2DN3, 2DXM, 2H35, 2HBC, 2HBD, 2HBE, 2HBF, 2HBS, 2HCO, 2HHD, 2HHE, 2M6Z, 2W6V, 2W72, 2YRS, 3B75, 3D17, 3D7O, 3DUT, 3HXN, 3IC0, 3IC2, 3KMF, 3NL7, 3NMM, 3ODQ, 3ONZ, 3OO4, 3OO5, 3P5Q, 3QJB, 3QJC, 3QJD, 3QJE, 3R5I, 3S65, 3S66, 3SZK, 3W4U, 3WCP, 3WHM, 4FC3, 4HHB, 4IJ2, 4L7Y, 4M4A, 4M4B, 4MQC, 4MQG, 4MQH, 4MQI, 4N7N, 4N7O, 4N7P, 4N8T, 4NI0, 4NI1, 4ROL, 4ROM, 4WJG, 4X0L, 4XS0, 5E29, 5E6E, 5EE4, 5HU6, 5JDO, 5KDQ, 5E83
Pengecam
Alias	HBB, CD113t-C, beta-globin, hemoglobin subunit beta, ECYT6
Pengecam-pengecam luaran	OMIM: 141900 MGI: 5474850 HomoloGene: 68066 GeneCards: HBB
Kedudukan gen (Manusia)
Kr.	Kromosom 11
Tamat	5,229,395 bp
Corak ekspresi RNA
	Top expressed in
	trabecular bone; ; Vena kava; ; periodontal fiber; ; monocyte; ; Sumsum tulang; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; bone marrow cell; ; glutes; ; darah;
	Top expressed in
	Sumsum tulang; ; limpa; ; neural tube; ; jantung; ; paru-paru; ; ganglionic eminence; ; ventricular zone; ; Otak tengah; ; esofagus; ; kawasan kulit;
	More reference expression data
	tiada data
Ontologi gen
Fungsi molekul	iron ion binding; oxygen binding; oxygen carrier activity; peroxidase activity; ikatan ion logam; hemoglobin binding; Pengikatan protein plasma; heme binding; haptoglobin binding;
Komponen sel	cytosol; endocytic vesicle lumen; blood microparticle; extracellular region; hemoglobin complex; extracellular exosome; haptoglobin-hemoglobin complex; tertiary granule lumen; ficolin-1-rich granule lumen; Ekstrasel;
Proses biologi	positive regulation of cell death; protein heterooligomerization; nitric oxide transport; positive regulation of nitric oxide biosynthetic process; oxygen transport; Penggumpalan; receptor-mediated endocytosis; regulation of blood pressure; bicarbonate transport; hydrogen peroxide catabolic process; platelet aggregation; response to hydrogen peroxide; renal absorption; cellular oxidant detoxification; neutrophil degranulation; transport;
	Sumber:Amigo / QuickGO
Ortolog
	3043
	101488143
	ENSG00000244734
	ENSMUSG00000073940
	P68871
	P02088
	NM_000518
	NM_008220
	NP_000509
	NP_032246; NP_001188320; NP_001265090
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Hemoglobin subunit beta (beta globin, β-globin) ialah sebuah protein globin yang dikodkan oleh gen HBB, dan bersama dengan globin alfa (HBA), membentuk bentuk hemoglobin yang paling biasa pada manusia dewasa, hemoglobin A (HbA). Panjangnya ialah 147 asid amino dan mempunyai berat molekul 15,867 Da. HbA manusia dewasa normal ialah heterotetramer yang terdiri daripada dua rantai alfa dan dua rantai beta.

HBB dikodkan oleh gen HBB di kromosom manusia 11. Mutasi dalam gen menghasilkan beberapa varian protein yang dikaitkan dengan gangguan genetik seperti penyakit sel sabit dan talasemia beta serta ciri-ciri bermanfaat seperti ketahanan genetik terhadap malaria. Sekurang-kurangnya 50 mutasi penyebab penyakit dalam gen ini telah ditemui.