Kalsitonin

Kalsitonin
Struktur sedia ada
PDB	Pencarian ortolog: PDBe RCSB
Senarai kod PDB
	2JXZ,%%s1LS7
Pengecam
Alias	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Pengecam-pengecam luaran	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
Kedudukan gen (Manusia)
Kr.	Kromosom 11
Tamat	14,972,351 bp
Corak ekspresi RNA
	Top expressed in
	Ganglion akar dorsal; ; trigeminal ganglion; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cerebellar vermis; ; Kelenjar pankreas; ; human kidney; ; Epithelium of choroid plexus; ; tibialis anterior muscle; ; right lobe of liver;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; lactiferous gland; ; merih; ; trigeminal ganglion; ; tian; ; tian; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ; ; ;
	Rujukan lanjutan untuk data ekspresi
Ontologi gen
Fungsi molekul	hormone activity; calcitonin receptor binding; Pengikatan protein plasma; identical protein binding; signaling receptor binding; protein-containing complex binding;
Komponen sel	Sitoplasma; Intrasel; extracellular region; akson; terminal bouton; soma; neuron projection; nukleus sel; Ekstrasel;
Proses biologi	cellular response to nerve growth factor stimulus; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of smooth muscle contraction; regulation of heart contraction; monocyte chemotaxis; negative regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; penuaan; vasodilation; cellular calcium ion homeostasis; response to heat; negative regulation of nervous system process; positive regulation of ossification; activation of adenylate cyclase activity; regulation of heart rate; detection of temperature stimulus involved in sensory perception of pain; negative regulation of ossification; response to pain; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; feeding behavior; inflammatory response; neuropeptide signaling pathway; negative regulation of transcription, DNA-templated; activation of protein kinase activity; embryo implantation; negative regulation of bone resorption; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; leukocyte cell-cell adhesion; G protein-coupled receptor internalization; positive regulation of interleukin-1 alpha production; response to yeast; negative regulation of osteoclast differentiation; cell-cell signaling; antibacterial humoral response; positive regulation of macrophage differentiation; receptor internalization; regulation of blood pressure; protein phosphorylation; vasculature development; defense response to Gram-negative bacterium; endothelial cell proliferation; positive regulation of interleukin-8 production; nervous system process involved in regulation of systemic arterial blood pressure; negative regulation of calcium ion transport into cytosol; Sistem imun semula jadi; endothelial cell migration; antifungal humoral response; defense response to Gram-positive bacterium; antimicrobial humoral immune response mediated by antimicrobial peptide; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	Sumber:Amigo / QuickGO
Ortolog
	796
	12310
	ENSG00000110680
	ENSMUSG00000030669
	P06881
	P70160; Q99JA0
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_001029125.1
NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1;
	NP_001276373.1
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Kalsitonin (juga dikenali sebagai tirokalsitonin) ialah suatu hormon polipeptida linear asid asid 32-amino yang dihasilkan di dalam manusia terutamanya oleh sel parafolikel (juga dikenali sebagai sel C) bagi tiroid, dan pada banyak lagi haiwan di dalam jasad ultimobrankium. Hormon ini bertindak untuk mengurangkan kalsium darah (Ca²⁺), bertentangan dengan kesan hormon paratiroid (PTH). Kalsitonin telah dijumpai pada ikan, reptilia, burung, dan mamalia. Kepentingannya pada manusia belum diasaskan dengan baik seperti kepentingannya pada haiwan lain, kerana fungsinya biasanya tidak ketara dalam pengawalaturan homeostasis kalsium normal. Hormon ini tergolong dalam keluarga protein seperti kalsitonin.