Faktor pertumbuhan seperti insulin 1

Faktor pertumbuhan seperti insulin 1
Struktur sedia ada
PDB	Pencarian ortolog: PDBe RCSB
Senarai kod PDB
	1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Pengecam
Alias	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Pengecam-pengecam luaran	OMIM: 147440 MGI: 96432 HomoloGene: 515 GeneCards: IGF1
Kedudukan gen (Manusia)
Kr.	Kromosom 12
Tamat	102,481,744 bp
Corak ekspresi RNA
	Top expressed in
	selaput jantung; ; tail of epididymis; ; tendon of biceps brachii; ; gastric mucosa; ; superficial temporal artery; ; Vesikel semen; ; Uretra; ; caput epididymis; ; corpus epididymis; ; endometrium;
	Top expressed in
	stria vascularis; ; internal carotid artery; ; efferent ductule; ; Iris mata; ; left lobe of liver; ; Pundi hempedu; ; stroma of bone marrow; ; genital tubercle; ; tisu adipos putih;
	More reference expression data
	; ; ; ;
	Rujukan lanjutan untuk data ekspresi
Ontologi gen
Fungsi molekul	hormone activity; insulin receptor binding; growth factor activity; integrin binding; Pengikatan protein plasma; insulin-like growth factor receptor binding;
Komponen sel	extracellular region; exocytic vesicle; insulin-like growth factor binding protein complex; platelet alpha granule lumen; insulin-like growth factor ternary complex; alphav-beta3 integrin-IGF-1-IGF1R complex; Membran plasma; Ekstrasel;
Proses biologi	positive regulation of transcription regulatory region DNA binding; skeletal system development; positive regulation of glucose import; muscle organ development; positive regulation of Ras protein signal transduction; response to heat; positive regulation of cardiac muscle hypertrophy; positive regulation of smooth muscle cell migration; Pengulangan DNA; positive regulation of insulin-like growth factor receptor signaling pathway; phosphatidylinositol 3-kinase signaling; positive regulation of DNA binding; Ras protein signal transduction; cell population proliferation; positive regulation of mitotic nuclear division; positive regulation of trophectodermal cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of fibroblast proliferation; ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; cell activation; negative regulation of oocyte development; positive regulation of transcription, DNA-templated; bone mineralization involved in bone maturation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPK cascade; proteoglycan biosynthetic process; positive regulation of activated T cell proliferation; positive regulation of epithelial cell proliferation; negative regulation of release of cytochrome c from mitochondria; protein stabilization; myotube cell development; positive regulation of DNA replication; myoblast proliferation; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; positive regulation of protein secretion; positive regulation of glycoprotein biosynthetic process; Peraturan ekspresi gen; phosphatidylinositol-mediated signaling; positive regulation of smooth muscle cell proliferation; muscle hypertrophy; protein kinase B signaling; regulation of multicellular organism growth; positive regulation of cell migration; platelet degranulation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of phosphatidylinositol 3-kinase signaling; myoblast differentiation; glycolate metabolic process; positive regulation of glycolytic process; negative regulation of smooth muscle cell apoptotic process; Transduksi isyarat; positive regulation of transcription by RNA polymerase II; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cell population proliferation; positive regulation of osteoblast differentiation; activation of protein kinase B activity; insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; positive regulation of gene expression; negative regulation of gene expression; cellular response to amyloid-beta; positive regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell apoptotic process; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; negative regulation of neuroinflammatory response; negative regulation of amyloid-beta formation;
	Sumber:Amigo / QuickGO
Ortolog
	3479
	16000
	ENSG00000017427
	ENSMUSG00000020053
	P05019
	P05017
	NM_000618; NM_001111283; NM_001111284; NM_001111285
NM_001111274; NM_001111275; NM_001111276; NM_010512; NM_184052;
	NM_001314010
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	NP_001104744; NP_001104745; NP_001104746; NP_001300939; NP_034642
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Faktor pertumbuhan seperti insulin 1 (insulin-like growth factor 1; IGF-1), juga dipanggil somatomedin C, ialah hormon yang serupa dalam struktur molekul dengan insulin yang memainkan peranan penting dalam pertumbuhan kanak-kanak, dan mempunyai kesan anabolik pada orang dewasa.

IGF-1 ialah protein yang pada manusia dikodkan oleh gen IGF1. IGF-1 terdiri daripada 70 asid amino dalam satu rantai dengan tiga jambatan disulfida intramolekul. IGF-1 mempunyai berat molekul 7,649 Dalton. Dalam anjing, mutasi purba dalam IGF1 adalah punca utama fenotip anjing mainan.

IGF-1 dihasilkan terutamanya oleh hati. Pengeluaran dirangsang oleh hormon pertumbuhan (GH). Kebanyakan IGF-1 terikat kepada salah satu daripada 6 protein pengikat (IGF-BP). IGFBP-1 dikawal oleh insulin. IGF-1 dihasilkan sepanjang hayat; kadar tertinggi pengeluaran IGF-1 berlaku semasa lonjakan pertumbuhan akil baligh. Tahap terendah berlaku pada peringkat bayi dan usia tua.

Analog sintetik IGF-1, mekasermin, digunakan pada kanak-kanak bagi rawatan kegagalan pertumbuhan.

Glisina-prolina siklik (cGP) ialah metabolit IGF-1. Ia mempunyai struktur kitaran, sifat lipofilik, dan stabil secara enzimatik, menjadikannya calon lebih baik dalam memanipulasi proses pelepasan-ikatan antara IGF-1 dan protein pengikatnya, seterusnya menormalkan fungsi IGF-1.