Gliseraldehid 3-fosfat dehidrogenase

Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Gliseraldehid 3-fosfat dehidrogenase, domain pengikat NAD
Gliseraldehid 3-fosfat dehidrogenase, domain pengikat NAD
	Penentu termokestabilan enzim diperhatikan di struktur molekulD-gliseraldehid 3-fosfat dehidrogenase Thermus aquaticus; resolusi 2.5 angstrom.
Pengenal pasti
Simbol	Gp_dh_N
Pfam	PF00044
Klan Pfam	CL0063
InterPro	IPR020828
PROSITE	PDOC00069
SCOP	1gd1
SUPERFAMILY	1gd1
Pfam
Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Glyceraldehyde-3-phosphate dehydrogenase
Struktur sedia ada
PDB	Pencarian ortolog: PDBe RCSB
Senarai kod PDB
	1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI
Pengecam
Alias	GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase
Pengecam-pengecam luaran	OMIM: 138400 MGI: 5434255 HomoloGene: 107053 GeneCards: GAPDH
Kedudukan gen (Manusia)
Kr.	Kromosom 12
Tamat	6,538,374 bp
Corak ekspresi RNA
	Top expressed in
	frontal pole; ; Pons; ; paraflocculus of cerebellum; ; Brodmann area 10; ; triceps brachii muscle; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; Brodmann area 46; ; lateral nuclear group of thalamus; ; body of tongue;
	tiada data
	More reference expression data
	tiada data
Ontologi gen
Fungsi molekul	transferase activity; microtubule binding; NAD binding; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; Pengikatan protein plasma; peptidyl-cysteine S-nitrosylase activity; NADP binding; identical protein binding; oxidoreductase activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; aspartic-type endopeptidase inhibitor activity; disordered domain specific binding;
Komponen sel	vesicle; nuclear membrane; membran; intracellular membrane-bounded organelle; microtubule cytoskeleton; lipid droplet; Membran plasma; perinuclear region of cytoplasm; GAIT complex; cytoskeleton; extracellular exosome; cytosol; nukleus sel; extracellular matrix; Sitoplasma; ribonucleoprotein complex;
Proses biologi	peptidyl-cysteine S-trans-nitrosylation; neuron apoptotic process; glukoneogenesis; negative regulation of translation; Glikolisis; canonical glycolysis; protein stabilization; cellular response to interferon-gamma; regulation of translation; microtubule cytoskeleton organization; regulation of macroautophagy; proses apoptosis; glucose metabolic process; negative regulation of endopeptidase activity; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sumber:Amigo / QuickGO
Ortolog
	2597
	100042025
	ENSG00000111640
	tiadadata
	P04406
	P16858
NM_002046; NM_001256799; NM_001289745; NM_001289746; NM_001357938;
	NM_001357943; NM_001357944
	XM_001476707
	NP_001243728; NP_001276674; NP_001276675; NP_002037; NP_001344872
	NP_001276655; NP_032110
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Gliseraldehid 3-fosfat dehidrogenase, domain terminal C

Struktur hablur gliseraldehid 3-fosfat dehidrogenase Pyrococcus horikoshii ot3

Pengenal pasti

Simbol

Gp_dh_C

Klan Pfam

InterPro

PROSITE

SCOP

SUPERFAMILY

Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Gliseraldehid 3-fosfat dehidrogenase (disingkat GAPDH) (EC 1.2.1.12) ialah enzim dengan berat kira-kira 37 kDa yang memangkinkan langkah keenam glikolisis, dan dengan itu, berfungsi untuk memecahkan glukosa untuk menghasilkan tenaga dan molekul karbon. Sebagai tambahan kepada fungsi metabolisme yang telah lama diketahui, GAPDH baru-baru ini diketahui terlibat dalam beberapa proses bukan metabolisme, termasuk pengaktifan transkripsi, permulaan apoptosis, pengulangalikan vesikel ER-Golgi dan pengangkutan aksoplasma. Dalam sperma, GAPDHS isoenzim khusus testis dinyatakan.