WNK1

WNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PWN
Identifiers
Aliases	WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
External IDs	OMIM: 605232; MGI: 2442092; HomoloGene: 14253; GeneCards: WNK1; OMA:WNK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	911,452 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	120,038,672 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; dorsal motor nucleus of vagus nerve; ; external globus pallidus; ; optic nerve; ; pars reticulata; ; trabecular bone; ; pars compacta; ; inferior olivary nucleus;
	Top expressed in
	endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; gastrula; ; right lung lobe; ; vestibular membrane of cochlear duct; ; saccule; ; primary oocyte; ; myocardium of ventricle; ; ciliary body; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase inhibitor activity; transferase activity; nucleotide binding; potassium channel inhibitor activity; phosphatase binding; protein kinase inhibitor activity; kinase activity; protein binding; chloride channel inhibitor activity; magnesium ion binding; protein serine/threonine kinase activity; ATP binding; protein kinase activity; protein kinase binding; protein kinase activator activity;
Cellular component	cytoplasm; cytosol; membrane;
Biological process	phosphorylation; negative regulation of phosphatase activity; neuron development; positive regulation of systemic arterial blood pressure; protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; peptidyl-threonine phosphorylation; negative regulation of pancreatic juice secretion; negative regulation of kinase activity; regulation of cellular process; ion transport; intracellular signal transduction; negative regulation of protein kinase activity; regulation of sodium ion transport; protein phosphorylation; negative regulation of sodium ion transport; activation of protein kinase activity; cellular response to calcium ion; positive regulation of canonical Wnt signaling pathway; positive regulation of T cell chemotaxis; peptidyl-serine phosphorylation; positive regulation of ion transmembrane transporter activity; negative regulation of cell-cell adhesion mediated by integrin; negative regulation of heterotypic cell-cell adhesion; negative regulation of GTPase activity; chemokine (C-C motif) ligand 21 signaling pathway; ion homeostasis; T cell receptor signaling pathway; lymphocyte migration into lymph node; negative regulation of leukocyte cell-cell adhesion; positive regulation of potassium ion import across plasma membrane; cellular response to chemokine; positive regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologs
	65125
	232341
	ENSG00000060237
	ENSMUSG00000045962
	Q9H4A3
	P83741
	NM_001184985; NM_014823; NM_018979; NM_213655
NM_001037155; NM_001185020; NM_001185021; NM_001199083; NM_001199084;
	NM_198703
	NP_001171914; NP_055638; NP_061852; NP_998820
	NP_001171949; NP_001171950; NP_001186012; NP_001186013; NP_941992
	Wikidata
View/Edit Human	View/Edit Mouse

WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the WNK1 gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regulation of cation-Cl⁻ cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney. CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell. WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).