Transcription factor II A

Transcription factor TF_IIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TF_IIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TF_IID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TF_IIB, TF_IIE, TF_IIF, and TF_IIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.