Cutamesine

Cutamesine
Names
	Preferred IUPAC name 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine
Identifiers
CAS Number	165377-43-5 ; dihydrochloride: 165377-44-6 ;
3D model (JSmol)	Interactive image; dihydrochloride: Interactive image;
ChEMBL	ChEMBL408867; dihydrochloride: ChEMBL3216524;
ChemSpider	8082975; dihydrochloride: 8130551;
DrugBank	DB06618;
PubChem CID	9907323; dihydrochloride: 9954941;
UNII	9J7A4144BX ; dihydrochloride: B66RO93FXQ ;
CompTox Dashboard (EPA)	DTXSID50167935 ;
	InChI InChI=1S/C23H32N2O2/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3 Key: UVSWWUWQVAQPJR-UHFFFAOYSA-N; dihydrochloride: InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H Key: XWOXAKBQEMQMFH-UHFFFAOYSA-N;
	SMILES COC1=C(OC)C=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1; dihydrochloride: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl;
Properties
Chemical formula	C23H32N2O2
Molar mass	368.521 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca²⁺ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.