Pleconaril

Pleconaril
Clinical data
Routes of; administration	Oral, intranasal
ATC code	J05AX06 (WHO) ;
Legal status
Legal status	?;
Pharmacokinetic data
Bioavailability	70% (oral)
Protein binding	>99%
Metabolism	Hepatic
Excretion	<1% excreted unchanged in urine
Identifiers
	IUPAC name 3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]; phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole;
CAS Number	153168-05-9 ;
PubChem CID	1684;
DrugBank	DB05105 ;
ChemSpider	1621 ;
UNII	9H4570Q89D;
ChEMBL	ChEMBL29609 ;
PDB ligand	W11 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID8057649 ;
ECHA InfoCard	100.208.947
Chemical and physical data
Formula	C18H18F3N3O3
Molar mass	381.355 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1nc(no1)c3cc(c(OCCCc2onc(c2)C)c(c3)C)C;
	InChI InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3 ; Key:KQOXLKOJHVFTRN-UHFFFAOYSA-N ;
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Pleconaril (Picovir) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus. It has shown useful activity against the dangerous enterovirus D68.

Clinical data


Routes of administration	Oral, intranasal
ATC code	J05AX06 (WHO)
Legal status
Legal status	?
Pharmacokinetic data
Bioavailability	70% (oral)
Protein binding	>99%
Metabolism	Hepatic
Excretion	<1% excreted unchanged in urine
Identifiers
IUPAC name 3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy] phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole
CAS Number	153168-05-9^N
PubChem CID	1684
DrugBank	DB05105^N
ChemSpider	1621^Y
UNII	9H4570Q89D
ChEMBL	ChEMBL29609^Y
PDB ligand	W11 (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID8057649
ECHA InfoCard	100.208.947
Chemical and physical data
Formula	C₁₈H₁₈F₃N₃O₃
Molar mass	381.355 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c1nc(no1)c3cc(c(OCCCc2onc(c2)C)c(c3)C)C
InChI InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3^Y Key:KQOXLKOJHVFTRN-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)