Orthodenticle homeobox 2

OTX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DMS
Identifiers
Aliases	OTX2, CPHD6, MCOPS5, Orthodenticle homeobox 2
External IDs	OMIM: 600037; MGI: 97451; HomoloGene: 11026; GeneCards: OTX2; OMA:OTX2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	56,816,693 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	48,911,276 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; retinal pigment epithelium; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; lateral nuclear group of thalamus; ; nasal epithelium; ; gonad; ; tibialis anterior muscle; ; substantia nigra; ; olfactory zone of nasal mucosa;
	Top expressed in
	pineal gland; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct; ; neural layer of retina; ; Epithelium of choroid plexus; ; lateral ventricle; ; choroid plexus of lateral ventricle; ; epiblast; ; embryo; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; eukaryotic initiation factor 4E binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	growth cone; nucleus; protein-containing complex;
Biological process	dopaminergic neuron differentiation; regulation of transcription, DNA-templated; positive regulation of gastrulation; regulation of fibroblast growth factor receptor signaling pathway; axon guidance; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of smoothened signaling pathway; forebrain development; positive regulation of embryonic development; primitive streak formation; midbrain development; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	5015
	18424
	ENSG00000165588
	ENSMUSG00000021848
	P32243
	P80206
	NM_001270523; NM_001270524; NM_001270525; NM_021728; NM_172337
NM_001286481; NM_001286482; NM_001286483; NM_144841; NM_001360225;
	NM_001360226
	NP_001257452; NP_001257453; NP_001257454; NP_068374; NP_758840
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein OTX2 is a protein that in humans is encoded by the OTX2 gene.