Jim O'Neill (investor)

Jim O'Neill
25th United States Deputy Secretary of Health and Human Services
Assumed office
June 9, 2025
PresidentDonald Trump
Preceded byAndrea Palm
Personal details
Children3
EducationYale University (BA)
University of Chicago (MA)
Occupation
  • Investor

James O'Neill is an American science and technology investor.

He served in several roles at the Department of Health and Human Services during the Bush administration, co-founded Peter Thiel's Thiel Fellowship in 2010, and served as chief executive officer (CEO) of SENS Research Foundation—a medical research organization focused on rejuvenation—from 2019 to July 2021.

O'Neill acted as CEO of the Thiel Foundation from 2009 to 2012, and was a managing director at Silicon Valley's Mithril Capital Management from 2012 to 2019. He has been a frequent critic of the Food and Drug Administration (FDA), and was considered by Donald Trump to lead the agency during his first presidential administration.

In 2025, President-elect Donald Trump nominated O'Neill to serve as United States deputy secretary of health and human services.