Gonadorelin

Gonadorelin
Clinical data

Trade names	Factrel, HRF, Kryptocur, Lutrelef, Lutrepulse, Relefact, others
Other names	Abbott 41070; AY-24031; Hoe-471; RU-19847
Routes of administration	intravenous, subcutaneous
Drug class	GnRH analogue; GnRH agonist; Progonadotropin
ATC code	H01CA01 (WHO) V04CM01 (WHO) QH01CA01 (WHO) QV04CM01 (WHO)
Legal status
Legal status	CA: ℞-only
Pharmacokinetic data
Metabolism	Hydrolysis
Elimination half-life	10–40 minutes
Identifiers
IUPAC name (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS Number	33515-09-2 71447-49-9 (diacetate) 51952-41-1 (hydrochloride)
PubChem CID	638793
DrugBank	DB00644
ChemSpider	33562
UNII	9O7312W37G
KEGG	C07607
ChEBI	CHEBI:5520
ChEMBL	ChEMBL1007
CompTox Dashboard (EPA)	DTXSID20873490
ECHA InfoCard	100.046.852
Chemical and physical data
Formula	C₅₅H₇₅N₁₇O₁₃
Molar mass	1182.311 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
InChI InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 Key:XLXSAKCOAKORKW-AQJXLSMYSA-N

Gonadorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which is used in fertility medicine and to treat amenorrhea and hypogonadism. It is also used in veterinary medicine. The medication is a form of the endogenous GnRH and is identical to it in chemical structure. It is given by injection into a blood vessel or fat or as a nasal spray.