2023 Guadalajara Open Akron – Singles

Maria Sakkari defeated Caroline Dolehide in the final, 7–5, 6–3 to win the singles title at the 2023 Guadalajara Open. She did not lose a set en route to her first WTA 1000 title and her second WTA Tour singles title overall, and her first WTA title since 2019, following six successive runner-up finishes. Dolehide reached her first WTA Tour singles final after saving four match points in the second set of the quarterfinals against Martina Trevisan. Ranked No. 111, she became the second finalist ranked outside the Top 100 after Svetlana Kuznetsova (ranked No. 153) since the introduction of the format in 2009.

Jessica Pegula was the reigning champion, but withdrew before the tournament began.